نوع مقاله : مقاله پژوهشی
1 گروه مهندسی نساجی، دانشکده فنی و مهندسی ، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
2 گروه مهندسی نساجی، دانشکده فنی و مهندسی، دانشگاه آزاد اسلامی واحد علوم و تحقیقات تهران، تهران، ایران، 1477893855
عنوان مقاله [English]
Electrospun nanofibers are a suitable substrate for loading a variety of drugs and extracts due to their controllable properties. In this study, chamomile extract was loaded as an antibacterial agent in polycaprolactone-polyethylene glycol nanofibers. For this purpose, 3: 2, 1: 1 and 2: 3 weight ratio of polycaprolactone-polyethylene glycol solutions were prepared and chamomile extract (7%) was added to the optimal composition and then electrospun. Morphology, cell compatibility, cytotoxicity, extract release and antibacterial properties of the resulting web were examined. Electron microscopy (SEM) images show a suitable and bead-less morphology for nanofiber PCL: PEG (2: 3) containing an extract with an average diameter of 211 ±70 nm. Interactions between the functional groups of polycaprolactone and polyethylene glycol and chamomile extract are observed in the FTIR spectra. The results of cell culture test indicate proper growth and proliferation of fibroblast cells on both chamomile extract loaded and non-loaded nanofibers. The results of MTT test, although confirming the non-toxicity of both extract loaded and non-loaded nanofibers, but the percentage of cell survival was higher on the sample containing chamomile extract. The results of antibacterial test confirm the antibacterial activities of polycaprolactone-polyethylene glycol nanofibers containing chamomile extract against both gram-positive and gram-negative bacteria.