Fabrication and characterization of chitosan nanofibrous scaffold containing hydroxyapatite/metal-organic framework (HAp@MOF) nanocomposite for bone tissue engineering applications

Articles in Press

Document Type : Research/ Original/ Regular Article

Authors

1 Department of Textile Engineering, Yazd University, P.O. Box 89195-741, Yazd, Iran

2 Department of Textile Engineering, Yazd University, Yazd, Iran

3 Department of Textile Engineering Yazd University

Abstract

In this study, chitosan-based nanofibrous scaffold containing hydroxyapatite/metal-organic framework (HAp@MOF) nanocomposite was prepared for potential application in tissue engineering. First, HAp@MOF nanocomposite was produced and characterized by in-situ synthesis of metal-organic framework, and then chitosan nanofibrous scaffold was produced using electrospinning method. Morphology, crystal structure, hydrophilic behavior and antibacterial activity of CS/PVA-HAp@MOF composite nanofibrous scaffold were studied and evaluated. For this purpose, scanning electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction, water contact angle and disk diffusion test were used. The investigation of the morphology of the composite nanofibrous scaffold showed the production of uniform and bead-free nanofibers with an average diameter of 113 nm. Also, the addition of HAp@MOF nanocomposite has increased the diameter of the fabricated fibers and increased the hydrophilic property with a contact angle of 57 degrees. Moreover, the investigations of antibacterial activity of nanofibrous scaffolds have indicated the appropriate performance of the nanofibrous scaffold containing HAp@MOF nanocomposite against the gram-positive bacteria Staphylococcus aureus and the gram-negative bacteria Escherichia coli. The obtained results showed that CS/PVA-HAp@MOF composite nanofibrous scaffold can be used as a good candidate for potential tissue engineering applications.

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Journal of Textile Science and Technology

Articles in Press, Accepted Manuscript
Available Online from 11 March 2024

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History

  • Receive Date: 16 January 2024
  • Revise Date: 11 March 2024
  • Accept Date: 11 March 2024

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