مروری بر کاربرد نانوالیاف در پزشکی

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی دانشگاه آزاد واحد یادگار امام خمینی (ره) شهرری- عضو باشگاه پژوهشگران جوان

2 عضو هیات علمی دانشگاه آزاد اسلامی واحد یادگار امام خمینی (ره)شهرری

3 دانشگاه آزاد واحدیادگار امام خمینی(ره)شهرری

چکیده

فناوری نانوالیاف رویکرد منحصر به فردی است که توجه بسیاری از محققان را به عنوان راه حلی برای چالش­های جاری در زمینه­های پزشکی همچون مراقبت­های سوختگی و زخم، بازسازی اعضای بدن ، درمان پوکی استخوان و بیماری­های مختلف مورد توجه قرار می دهد. طراحی داربست، نقش تعیین کننده ای در این زمینه دارد. الکتروریسی از متداول ترین روش­ها برای تولید نانوالیاف با نسبت سطح به حجم و تخلخل زیاد است که می تواند شرایط مشابه ماتریس خارج سلولی(ECM)  را فراهم کند. این امر به دلیل مقیاس نانومتری قطر الیاف ECM است که می تواند با روش الکتروریسی و همچنین ساختار متخلخل آن شبیه سازی شود. در این بررسی، کاربرد نانوالیاف در شاخه­های مختلف پزشکی مانند مهندسی بافت، رهایش دارو و پانسمان زخم در سال­های اخیر مورد مطالعه قرار گرفته است. این بررسی فرصت­هایی را برای توسعه مواد و تکنیک­های جدید فراهم می کند که توانایی ایجاد روش­های تحلیلی سریع، دقیق و قابل اطمینان را بهبود می بخشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

A review on the medical application of electrospun nanofibers

نویسندگان [English]

  • Atiyeh Ghajarieh 1
  • Sima Habibi 2
  • Azam Talebian 3
1 Textile department , Yadegar-e-Imam Khomeini(RAH) shahr-e-Rey branch
2 textile department , Islamic Azad University Yadegar -e-Imam Khomeini (RAH) shar-e Rey branch
3 Islamic azad university yadegar-e-Imam khomeini(RAH) Shahr-e-Rey branch
چکیده [English]

Nanofiber technology is an exciting research area that has attracted the attention of several researchers as a potential solution to the current challenges in the biomedical field for wound dressing, organ repair, and treatment for osteoporosis. Nanofibrous meshes mimic the porous structure of the natural extracellular matrix (ECM); hence they are advantageous for tissue regeneration and can be used for sustaining the release of encapsulated drug or growth factor. Electrospinning is one of the most common methods for the fabrication of nanofibrous meshes, with very high surface area to volume ratio and porous structure, for various biomedical and tissue engineering applications.  The electrospun meshes can be used for making scaffolds similar in physical structure to that of ECM. The electrospun nanofibers mimic the ECM nano-fibrils and porous structure. In this review, the applications of nanofibers in various biomedical areas such as tissue engineering, drug delivery and wound dressing are summarized. This provides an overview of the development of new materials and techniques to be used in biomedical engineering applications and reliable analytical techniques for their characterization.

کلیدواژه‌ها [English]

  • drug delivery
  • electrospinning
  • nanofiber
  • tissue engineering
  • wound dressing

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  • تاریخ دریافت: 06 فروردین 1398
  • تاریخ بازنگری: 13 اردیبهشت 1398
  • تاریخ پذیرش: 22 اردیبهشت 1398

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